abstract：:PTSD arises by definition as a direct consequence of the experience of an acute severe stressor. The formation of traumatic memory and its extinction, sympathetic and adrenocortical stress systems activity in relation to individual vulnerability form the core of animal models for PTSD. ...

journal_title：Progress in brain research

authors： Oitzl MS

更新日期：2008-01-01 00:00:00

abstract：:The midbrain has been shown to contain crucial nuclei for the control of vertical and torsional eye movements. Recent studies in monkeys demonstrated that midbrain lesions also affect head movements during gaze saccades, but so far clinical reports on the matter have been missing. We measured 3D eye and head movements...

journal_title：Progress in brain research

authors： Kremmyda O,Glasauer S,Eggert T,Büttner U

更新日期：2008-01-01 00:00:00

abstract：:Downbeat nystagmus (DBN) is the most frequent form of acquired persisting fixation nystagmus. It is hypothesized to occur when physiological inhibitory cerebellar input, namely of the flocculus, to the vestibular nuclei is inhibited. The second most frequent form of acquired nystagmus is upbeat nystagmus (UBN). UBN is...

journal_title：Progress in brain research

authors： Strupp M,Kalla R,Glasauer S,Wagner J,Hüfner K,Jahn K,Brandt T

更新日期：2008-01-01 00:00:00

abstract：:Human and nonhuman primates predictively use smooth pursuit and saccades to track visual targets that move in a fronto-parallel plane. This behaviour is believed to be facilitated by short-term memory of the target motion and/or an efference copy of the subject's motor effort. Subjects in our experiments tracked dicho...

journal_title：Progress in brain research

authors： Fu P,Chang R,O'Beirne K,King WM

更新日期：2008-01-01 00:00:00

abstract：:Predictive processes are widespread in the motor and sensory areas of the primate brain. They enable rapid computations despite processing delays and assist in resolving noisy, ambiguous input. Here we propose that the frontal eye field, a cortical area devoted to sensorimotor aspects of eye movement control, implemen...

journal_title：Progress in brain research

authors： Crapse TB,Sommer MA

更新日期：2008-01-01 00:00:00

abstract：:We present results of a study of torsional eye movements evoked by earth-vertical accelerations along the subject's longitudinal axis. The earth-vertical stimulus leads to a gravito-inertial acceleration vector that changes magnitude but not direction. It can therefore be viewed as a dynamic change of the gravity leve...

journal_title：Progress in brain research

authors： Olasagasti I,Bockisch CJ,Zee DS,Straumann D

更新日期：2008-01-01 00:00:00

abstract：:Two cortical areas that crucially contribute to the generation and maintenance of smooth pursuit eye movements (SPEM) are the medial superior temporal area (MST) and the pursuit area of the frontal eye fields (FEF). They both project to the brainstem premotor structures via different parallel pathways. A special prope...

journal_title：Progress in brain research

authors： Nuding U,Ono S,Mustari MJ,Büttner U,Glasauer S

更新日期：2008-01-01 00:00:00

abstract：:Impulsive testing, which accurately measures the gain of the vestibulo-ocular reflex (VOR) is mostly recorded from only one eye. We measured the horizontal VOR of both eyes in response to graded velocity head impulses in 14 normal subjects. VOR acceleration gains were similar for each eye in both directions at low acc...

journal_title：Progress in brain research

authors： Weber KP,Aw ST,Todd MJ,McGarvie LA,Pratap S,Curthoys IS,Halmagyi GM

更新日期：2008-01-01 00:00:00

abstract：:Saccadic oscillations are unwanted back-to-back saccades occurring one upon the other that produce a high-frequency oscillation of the eyes (usually 15-30 Hz). These may occur transiently in normal subjects, for example, around the orthogonal axis of a purely horizontal or vertical saccade, during combined saccade-ver...

journal_title：Progress in brain research

authors： Ramat S,Leigh RJ,Zee DS,Shaikh AG,Optican LM

更新日期：2008-01-01 00:00:00

abstract：:The visual system is tied to the retina. Because the eyes move in the orbit, and the head moves on the body, accurate location of an object in extrapersonal space cannot simply result from a visual signal. Instead, the retinal signal must be combined with an estimate of where the eyes are in the orbit, and where the h...

journal_title：Progress in brain research

authors： Zhang M,Wang X,Goldberg ME

更新日期：2008-01-01 00:00:00

abstract：:Poor control of attention-related and motor processes, often associated with behavioural or cognitive impulsivity, are typical features of children and adults with attention-deficit hyperactivity disorder (ADHD). Until recently clinicians have observed little need to improve on or add to the catecholaminergic model fo...

journal_title：Progress in brain research

authors： Oades RD

更新日期：2008-01-01 00:00:00

abstract：:The serotonin (5-HT) neurotransmitter system provides fundamental modulatory regulation of the limbic-corticostriatal circuitry known to be vital in the development of addiction as well as the aspects of addiction that hinder recovery and contribute to relapse. Thus, components of the 5-HT system may provide novel tar...

journal_title：Progress in brain research

authors： Bubar MJ,Cunningham KA

更新日期：2008-01-01 00:00:00

abstract：:The present chapter outlines current thinking regarding serotonin and dopamine in schizophrenia. Each has individually been linked to theories regarding the illness' pathophysiology although the focus here is on their interactive role, a model that has driven drug development in the field for the last 10-15 years. Wit...

journal_title：Progress in brain research

authors： Remington G

更新日期：2008-01-01 00:00:00

abstract：:This chapter describes current findings from the research into postoperative cognitive dysfunction (POCD) following cardiac and non-cardiac surgery in older adults. The evidence suggests that a significant proportion of patients show POCD in the early weeks following surgery and anesthesia. Specific domains of cogniti...

journal_title：Progress in brain research

authors： Caza N,Taha R,Qi Y,Blaise G

更新日期：2008-01-01 00:00:00

abstract：:In our overview, we will attempt to justify the use of animal models and suggest that it is the only way to make the successive transitions between changes occurring at the molecular and cellular levels and changes at the level of behaviour in the intact organism. We will also stress the importance of criteria that ha...

journal_title：Progress in brain research

authors： Castellucci VF

更新日期：2008-01-01 00:00:00

abstract：:The hippocampus is crucial for the consolidation of new declarative long-term memories. Genetic and behavioral experimentation have revealed that several protein kinases are critical for the formation of hippocampus-dependent long-term memories. Cyclic-AMP dependent protein kinase (PKA) is a serine-threonine kinase th...

journal_title：Progress in brain research

authors： Abel T,Nguyen PV

更新日期：2008-01-01 00:00:00

abstract：:The chapter reviews a classical Indian model of consciousness found in the Abhidhamma, a collection of seven treatises in the Pali Canon Tipitaka. The model was based on observations made during advanced vipassana practice, a first-person method taught by the Buddha. The climax of the model consists in the elucidation...

journal_title：Progress in brain research

authors： Banerjee R

更新日期：2008-01-01 00:00:00

abstract：:Modern philosophy of mind cannot be understood without recent developments in computer science, artificial intelligence (AI), robotics, neuroscience, biology, linguistics, and psychology. Classical philosophy of formal languages as well as symbolic AI assume that all kinds of knowledge must explicitly be represented b...

journal_title：Progress in brain research

authors： Mainzer K

更新日期：2008-01-01 00:00:00

abstract：:Tinnitus has many similarities with the symptoms of neurological disorders such as paresthesia and central neuropathic pain. There is considerable evidence that the symptoms and signs of some forms of tinnitus and central neuropathic pain are caused by functional changes in specific parts of the central nervous system...

journal_title：Progress in brain research

authors： Møller AR

更新日期：2007-01-01 00:00:00

abstract：:The idea of the dentate gyrus as a gate or filter at the entrance to the hippocampus, blocking or filtering incoming excitation from the entorhinal cortex, has been an intriguing one. Here we review the historical development of the idea, and discuss whether it may be possible to be more specific in defining this gate...

journal_title：Progress in brain research

authors： Hsu D

更新日期：2007-01-01 00:00:00

abstract：:Since the discovery of nerve growth factor (NGF) in the 1950s and brain-derived neurotrophic factor (BDNF) in the 1980s, a great deal of evidence has mounted for the roles of neurotrophins (NGF; BDNF; neurotrophin-3, NT-3; and neurotrophin-4/5, NT-4/5) in development, physiology, and pathology. BDNF in particular has ...

journal_title：Progress in brain research

authors： Binder DK

更新日期：2007-01-01 00:00:00

abstract：:Network oscillations are proposed to provide the framework for the ongoing neural computations of the brain. Thus, an important aspect of understanding the functional roles of various cell classes in the brain is to understand the relationship of cellular activity to the ongoing oscillations. While many studies have c...

journal_title：Progress in brain research

authors： Henze DA,Buzsáki G

更新日期：2007-01-01 00:00:00

abstract：:There has been substantial progress in our understanding of the hippocampus in the past 70 years. During this time, it has become clear that the hippocampus is not an olfactory-related structure alone, but plays critical roles in other functions that do not necessarily depend on olfaction, such as learning and memory....

journal_title：Progress in brain research

authors： Seress L

更新日期：2007-01-01 00:00:00

abstract：:Sub-lethal exposure to practically any harmful stimulus has been shown to induce consequent protection against more severe stress. This preconditioning (PC) effect may be achieved by exposure to different stressors, indicating that the induction of tolerance involves activation of common protective pathways. Chronic e...

journal_title：Progress in brain research

authors： Shein NA,Horowitz M,Shohami E

更新日期：2007-01-01 00:00:00

abstract：:Acute spinal cord injury (SCI) is a devastating neurological disorder that can affect any individual at a given instance. Current treatment options for SCI include the use of high dose methylprednisolone sodium succinate, a corticosteroid, surgical interventions to stabilize and decompress the spinal cord, intensive m...

journal_title：Progress in brain research

authors： Baptiste DC,Fehlings MG

更新日期：2007-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) research to date has focused almost exclusively on the pathophysiology of injured neurons with very little attention paid to non-neuronal cells. However in the past decade, exciting discoveries have challenged this century-old view of passive glial cells and have led to a reinterpretation ...

journal_title：Progress in brain research

authors： Floyd CL,Lyeth BG

更新日期：2007-01-01 00:00:00

abstract：:A neural-network module with attractor dynamics has been shown recently to be robust to stochastic noise in external and internal signals, and to converge rapidly onto an output signal that is an unbiased and efficient representation of the environment. We suggest here a modular network architecture with attractor dyn...

journal_title：Progress in brain research

authors： Krouchev NI,Kalaska JF

更新日期：2007-01-01 00:00:00

abstract：:A computational model of the mammalian spinal cord circuitry incorporating a two-level central pattern generator (CPG) with separate half-center rhythm generator (RG) and pattern formation (PF) networks is reviewed. The model consists of interacting populations of interneurons and motoneurons described in the Hodgkin-...

journal_title：Progress in brain research

authors： McCrea DA,Rybak IA

更新日期：2007-01-01 00:00:00

abstract：:Object recognition and visual attention are tightly linked processes in human perception. Over the last three decades, many models have been suggested to explain these two processes and their interactions, and in some cases these models appear to contradict each other. We suggest a unifying framework for object recogn...

journal_title：Progress in brain research

authors： Walther DB,Koch C

更新日期：2007-01-01 00:00:00

abstract：:The dorsal striatum (caudate putamen) contains two types of GABAergic medium spiny neurons (MSNs) that are distinguished by the expression of either the opioid peptide, enkephalin, or the opioid peptide, dynorphin, as well as the tachykinin substance P. Pharmacological studies suggest that these peptides modulate loca...

journal_title：Progress in brain research

authors： McGinty JF

更新日期：2007-01-01 00:00:00

abstract：:In the neostriatum, GABAergic inhibition arises from the action of at least two classes of inhibitory interneurons, and from recurrent collaterals of the principal cells. Interneurons receive excitatory input only from extrinsic sources, and so act in a purely feedforward capacity. Feedback inhibition arises from the ...

journal_title：Progress in brain research

authors： Wilson CJ

更新日期：2007-01-01 00:00:00

abstract：:Most people are experts in face recognition. We propose that the special status of this particular body part in telling individuals apart is the result of a developmental process that heavily biases human infants and children to attend towards the eyes of others. We review the evidence supporting this proposal, includ...

journal_title：Progress in brain research

authors： Gliga T,Csibra G

更新日期：2007-01-01 00:00:00

abstract：:Objects have specific cognitive attributes, elicit particular visuo-motor responses, and require visual processes beyond primary visual cortex to combine information over extended regions as a basis for the segmentation and integration of visual objects. As well as segmentation, the assignment of region boundaries to ...

journal_title：Progress in brain research

authors： Braddick O,Atkinson J

更新日期：2007-01-01 00:00:00

abstract：:In this chapter, the distribution of Hsp70 in brain cell types following whole body hyperthermia is reviewed. The prevalence of Hsp70 expression in oligodendrocytes, microglia, and vascular cells in this type of stress contrasts with scarcity of Hsp70 induction in astrocytes and most neurons of the hyperthermic brain....

journal_title：Progress in brain research

authors： Pavlik A,Aneja IS

更新日期：2007-01-01 00:00:00

abstract：:The recent increase in the frequency and intensity of killer heat waves across the globe has aroused worldwide medical attention to exploring therapeutic strategies to attenuate heat-related morbidity and/or mortality. Death due to heat-related illnesses often exceeds >50% of heat victims. Those who survive are crippl...

journal_title：Progress in brain research

authors： Sharma HS

更新日期：2007-01-01 00:00:00

abstract：:Recent accounts of tinnitus development and maintenance assign an important role to central mechanisms. Residual inhibition is a frequent phenomenon in individuals with tinnitus, and refers to the fact that tinnitus can temporarily be reduced by presenting sounds or noises that inhibit tinnitus for a limited time even...

journal_title：Progress in brain research

authors： Struve M,Diesch E,Flor H

更新日期：2007-01-01 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive method used to induce electrical current in the brain through impulses of strong magnetic fields applied externally. The technique can relieve tinnitus by modulating the excitability of neurons in the auditory cortex to decrease the hyperexcitabilit...

journal_title：Progress in brain research

authors： Kleinjung T,Steffens T,Londero A,Langguth B

更新日期：2007-01-01 00:00:00

abstract：:Antidepressants are commonly prescribed for tinnitus. Research thus far provides some support for that treatment, but the literature also raises concerns because tinnitus is a side effect of antidepressant medication. In this chapter, four published double blind placebo-controlled trials of antidepressants for tinnitu...

journal_title：Progress in brain research

authors： Robinson S

更新日期：2007-01-01 00:00:00

abstract：:Susceptibility to chronic tinnitus is highly variable and of particular interest when it comes to defining strategies for prevention and treatment. While several rare monogenic disorders have been described that are associated with tinnitus, the genetic underpinnings of the more common forms of the syndrome are still ...

journal_title：Progress in brain research

authors： Sand PG,Langguth B,Kleinjung T,Eichhammer P

更新日期：2007-01-01 00:00:00

abstract：:It has been tacitly assumed that a long descending motor tract axon consists of a private line connecting the cell of origin to a single muscle, as a motoneuron innervates a single muscle. However, this notion of a long descending motor tract referred to as a private line is no longer tenable, since recent studies hav...

journal_title：Progress in brain research

authors： Shinoda Y,Sugiuchi Y,Izawa Y,Hata Y

更新日期：2006-01-01 00:00:00